Day of the Doodler
Coin flips, erased items, and Blank Canvases race the timer upward.
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Challenge mode
Challenges
Thirteen co-op boss challenges — pick a scenario, set a difficulty, and beat the final boss before the timer runs out.
Delirious
Unrelenting Delirium copies souls and challenge slot monsters while being attacked.
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Fatty's Feast
Engorged Mega Fatty devours monsters at end of turn and grows from feast counters.
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Greed's Gamble
Greed grows stronger from coin loss while Keeper Heads pile up.
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How the Krampus Stole Christmas
Protect the presents before Krampus steals them all.
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Live, Laugh, Lust
Lust counters escalate monsters while love counters defend the players.
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Lord of the Flies
Convert the swarm from the Duke to the player characters and overcome the shield of flies.
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Masquerade
The mask twists every attack. Mistaken Identity chooses what you must attack before the target is chosen.
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Motherly Love
Devout Mom can only be beaten through The Bible and a shifting Mom deck.
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Resurrection Day
Rag Man's power grows. Defeat Resurrected Rag Man before the timer runs out!
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Stomping Ground
Marauding Daddy Long Legs spreads stomp counters that burst at turn end.
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Trick or Treat
A shifting challenge where Trick punishes attacks and Treat sweetens rewards.
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Who Am I?
Cycle identities through destinies, then face Fragmenting Isaac in the Last Stand.
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